Implications of ejaculatory sperm DNA fragmentation on male infertility management

Implications of ejaculatory sperm DNA fragmentation on male infertility management

Clinical aspects of sperm DNA fragmentation detection and male infertility.

Over the past 25 years, various methods have been developed to measure sperm DNA strand breaks in situ. Currently, there are four major tests of sperm DNA fragmentation, including the Comet, Tunel, sperm chromatin structure assay (SCSA) and the acridine orange test (AOT). The Comet assay is a light microscope technique where the sperm cells are mixed with melted agarose and then placed on a gla...

Insights on the predictive accuracy of the sperm DNA fragmentation tests on male infertility

tau.amegroups.com © Translational Andrology and Urology. All rights reserved. Dr. El-Sakka in his commentary on the “Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios” by Agarwal et al. (1), has generally acknowledged the importance of clinical scenarios in remedying the current sperm DNA fragmentation (SDF) debate and identifying the prop...

An evidence-based perspective on the role of sperm chromatin integrity and sperm DNA fragmentation testing in male infertility

tau.amegroups.com © Translational Andrology and Urology. All rights reserved. We read with interest the commentary by Dr. Pandiyan and colleagues (1) about the merit of our recently published clinical practice guidelines for sperm DNA fragmentation (SDF) testing based on clinical scenarios (2). We noted that these authors were quite skeptic about the integration of SDF testing into the clinical...

The role of sperm DNA testing on male infertility